Current Issue : January-March Volume : 2025 Issue Number : 1 Articles : 1 Articles
Propranolol hydrochloride is sympatholytic nonselective beta blocker. It is used to treat hypertension, anxiety and panic. Due to its short half life 3-4 hrs, conventional tablet of Propranolol required frequent dosing that can cause various side effects such as dizziness, uneven heart beats, shortness of breath etc. The present work was aimed to formulate superporous hydrogel of Propranolol. Superporous hydrogel (SPH) were synthesized by using gas blowing technique. Acrylamide and acrylic acid were used as hydrophillic monomers; bisacrylamide (BIS) as a cross linker, distilled deionized water and pluronic F-127 as a foam stabilizer were included in the composition of SPH. Chitosan as a secondary polymer, ammonium per sulphate (APS) as an redox initiator and N,N,N’,N’-tetramethylethylenediamine (TEMED) as a catalyst were taken. Morphological characterization of SPH was carried out with the help of scanning electron microscopy (SEM) at different magnifications. DSC thermogram of drug represented the sharp endothermic peak at 165.7°C and thermogram of drug loaded SPH showed endothermic peaks at 164.8°C. It was observed that Swelling ratio was increased when chitosan concentration was increased from 0.5-1.0 % w/v. Mechanical strength of all formulation of SPH was found to be in the range of 4900- 6200 N/m2. Highest drug loading inside FC2 formulation was observed due to highest swelling ratio and strong interpenetrating network formation. Drug entrapment efficiency increased up to some extent when chitosan concentration increased from 0.5-1.0 %....
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